Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension
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منابع مشابه
Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension.
Exposure of the early gestation ovine fetus to exogenous glucocorticoids induces organ-specific alterations in postnatal cardiovascular physiology. To determine whether early gestation corticosteroid exposure alters coronary reactivity before the development of systemic hypertension, dexamethasone (0.28 mg x kg(-1) x day(-1)) was administered to pregnant ewes by intravenous infusion over 48 h b...
متن کاملEarly gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension.
Exposure of the early gestation ovine fetus to exogenous glucocorticoids induces alterations in postnatal cardiovascular physiology, including hypertension. To determine whether autonomic function and systemic vascular reactivity are altered by in utero programming before the development of systemic hypertension, we examined arterial baroreflex function and in vivo hemodynamic and in vitro vasc...
متن کاملEarly gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity.
Excessive exposure of the fetus to maternally derived corticosteroids has been linked to the development of adult-onset diseases. To determine if early gestation corticosteroid exposure alters subsequent coronary artery reactivity, we administered dexamethasone (0.28 mg.kg(-1).day(-1)) to pregnant ewes at 27-28 days gestation (term being 145 days). Vascular responsiveness was assessed in endoth...
متن کاملCALL FOR PAPERS Fetal Physiological Programming Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity
Roghair, Robert D., Fred S. Lamb, Francis J. Miller, Jr. Thomas D. Scholz, and Jeffrey L. Segar. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol Regul Integr Comp Physiol 288: R46–R53, 2005. First published June 24, 2004; doi:10.1152/ajpregu.00165. 2004.—Excessive exposure of the fetus to maternally derived corticosteroids has be...
متن کاملCoronary endothelial function and vascular smooth muscle proliferation are programmed by early-gestation dexamethasone exposure in sheep.
Exposure of the early-gestation ovine fetus to exogenous glucocorticoids induces changes in postnatal cardiovascular physiology. We sought to characterize coronary artery vascular function in this model by elucidating the contribution of nitric oxide and reactive oxygen species to altered coronary vascular reactivity and examining the proliferative potential of coronary artery vascular smooth m...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2005
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00369.2005